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  • Use of Integrated Data Analysis to Gain an Advantage in Biomarker Discovery and Personalized ...

    Saturday, October 01, 2011
    Technical Article
    Jens Hoefkens
    The genomic revolution of the last two decades has provided pharmaceutical companies with an almost overwhelming number of potential drug targets. read more

  • Improved Long-Term Culture Using A Microfluidic Platform

    Monday, October 07, 2013
    Application Note
    Alex Mok Paul Hung Cindy Chen Sónia Gil Kathleen Ongena
    Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

  • DNA in Forensics

    Wednesday, August 28, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more

  • Multiparameter Pluripotency Analysis Using Magnetic Bead Assays

    Wednesday, August 28, 2013
    Application Note
    Nikolai Stankiewicz Thomas Siegl Frederick Wiese
    For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ... read more

  • Impact of New Pipetting Techniques on Safety in the Laboratory

    Monday, September 02, 2013
    Application Note
    Bobby Chavli Annette Summers Mary Napier
    According to the Occupational Safety and Health Administration (OSHA), on average, it takes between 18 and 36 months to develop and implement a new regulation, trailing the pace of science. As a ... read more

  • High-Throughput Screening of Multiple Protein Complexes

    Thursday, July 04, 2013
    Application Note
    Imre Berger Maxime Chaillet Frederic Garzoni Sinyee Yau-Rose Barney Zoro
    Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ... read more

  • Measurement of IL-6 RNA Levels in Live Cells

    Wednesday, July 10, 2013
    Application Note
    Shobana Vaidyanathan
    Infections and tissue damage lead to acute inflammatory responses, orchestrated by the release of cytokines from macrophages and mast cells, as well as endothelium and tumor cells. Tumor necrosis ... read more

  • Putting the “More” in Morphology: Part 2

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more

  • Detection of siRNA-Mediated Gene Modulation Using RNA Detection Probes

    Monday, May 20, 2013
    Application Note
    Don Weldon Grace Johnston
    To study the function of genes and biological pathways, researchers often use techniques such as RNA interference (RNAi) to modify gene expression. In RNAi experiments, it is important to determine ... read more

  • Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Friday, June 07, 2013
    Application Note
    Amedeo Cappione Masaharu Mabuchi David Briggs Timothy Nadler
    Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more

  • High-Content Analysis (HCA 2013): 3-D Reduces the Gap Between In Vitro and In Vivo

    Tuesday, February 05, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The 10th High-Content Analysis meeting attracted about 300 scientists to San Francisco’s Fairmont Hotel (January 8–11, 2013). A Venn diagram of attendees would certainly include overlapping circles ... read more

  • Light Engines for the Life Sciences

    Thursday, September 04, 2008
    Technical Article
    Arlie R. Conner Claudia B. Jaffe Steven M. Jaffe
    Life science instruments present unique challenges to suppliers of light-generation equipment: Inexpensive, high-intensity, uniform, monochromatic light across a broad UV-VIS-IR spectrum is required... read more

  • High-Throughput Cell Cycle Analysis Using a Microplate Cytometer

    Friday, November 28, 2008
    Technical Article
    Paul Wylie
    The traditional method of determining the cell cycle phase of individual cells is by quantifying their total DNA content using flow cytometry. read more

  • Bioassays and Bioanalytical Method Development 2013

    Tuesday, November 12, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Biotherapeutics are generally large molecules with a heterogeneous complex structure that is directly related to their ability to modulate biological reactions. This precludes defining a meaningful ... read more

  • Single-Cell RNA Detection to Identify Cell Subpopulations in Heterogeneous Mixtures

    Tuesday, March 25, 2014
    Application Note
    Don Weldon Victor Koong Alex Ko Yuko Williams Laura White
    Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or... read more
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